The Double Non-Helix

By Ken Biegeleisen, M.D., Ph.D.

W-C helical structure in de-proteinized crystals.


DNA structure in living systems:  non-helical!


If you can patiently work your way through these presentations, you will come to realize that the Watson-Crick double-helix structure may be mainly an artifact of deproteinization and crystallization.

(Working scientists: If you regularly perform agarose gel electrophoresis of DNA, click here to learn how you can get involved in the process of establishing the role of non-helical DNA structure in living systems.)















This presentation, on protamine-DNA structure, was created in 2005. The brief section on histone structure (slides 12-30) has been vastly superceded by the three presentations above, namely "Histone Structure, Parts I-III". That notwithstanding, the other 220 slides shown here are as important today as when they were first created.

All who are truly interested in nucleoprotein structure owe it to themselves to watch this.







Read the published manuscripts:


Ken Biegeleisen, M.D., Ph.D.
19 East 80 Street, Suite 1E
New York, N.Y. 10075
United States of America
Tel: (212) 717-4422